The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) convened an expert panel to re-evaluate the reproductive and developmental toxicities of di(2-ethylhexyl)phthalate (DEHP). A previous CERHR Expert Panel had evaluated DEHP in 1999-2000. However, since release of the earlier CERHR Expert Panel Report on DEHP, approximately 150 papers relevant to human exposure and reproductive and/or developmental toxicity of DEHP have been published. The CERHR decided to update the evaluation of DEHP because of: (1) widespread human exposure, (2) public and government interest in potential adverse health effects, and (3) the large number of relevant papers published since the earlier evaluation. The expert panel meeting was held October 10-12, 2005, in Alexandria, VA. This is the first time a CERHR expert panel was convened to update an evaluation conducted by an earlier expert panel.