DEHP

The Weight of the Evidence on DEHP: Exposures are a Cause for Concern, Especially During Medical Care

  • Tipo de documento: PDF
  • Idioma: English

Assessments conducted for the governments of the United States, Canada, and the European Union have all concluded that exposures to di-2-ethylhexyl phthalate (DEHP) are of concern to some patient populations and subsets of the general public. Especially vulnerable are infants and toddlers, pregnant and lactating women, and patients undergoing certain medical procedures. All of the government-sponsored assessments point to the need for action, with the Canadian and Swedish studies recommending specific action to reduce DEHP exposure in health care and other vulnerable populations.

Meeting Summary: Expert Panel Re-Evaluation of DEHP

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The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) convened an expert panel to re-evaluate the reproductive and developmental toxicities of di(2-ethylhexyl)phthalate (DEHP). A previous CERHR Expert Panel had evaluated DEHP in 1999-2000. However, since release of the earlier CERHR Expert Panel Report on DEHP, approximately 150 papers relevant to human exposure and reproductive and/or developmental toxicity of DEHP have been published.

Safety Assessment of DEHP Released from PVC Medical Devices

  • Tipo de documento: PDF
Patients undergoing medical procedures such as IV therapy, enteral and parenteral nutrition support, blood transfusion, hemodialysis and peritoneal dialysis, cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) can be exposed to di-(2-ethylhexyl)phthalate (DEHP), a compound used as a plasticizer for polyvinyl chloride (PVC) medical devices. DEHP has been shown to produce a wide range of adverse effects in experimental animals, notably liver toxicity and testicular atrophy.

Neonatal Exposure to DEHP (di-2-ethylhexyl phthalate) and Opportunities for Prevention

  • Tipo de documento: PDF
  • Idioma: English

Human exposure to DEHP occurs throughout life. The exposure to this toxic chemical begins in the womb, rises dramatically for premature infants and newborns requiring intensive care in a neonatal unit, and declines with their removal from intravenous, enteral feeding and oxygen therapy systems and their arrival at home. The report reviews the various points of exposure to DEHP and ways to prevent such exposures.

Why Health Care is Moving Away from the Hazardous Plastic Polyvinyl Chloride (PVC)

  • Tipo de documento: PDF
  • Idioma: English

PVC, or “vinyl” as it is often called, has some advantageous attributes, including flexibility, transparency, and strength. But PVC can also adversely impact human health and the environment. A chemical used to make PVC flexible is leaching out of PVC medical devices and exposing patients. That chemical, di-2-ethylhexyl-phthalate (DEHP), is a reproductive toxicant. For this reason, many hospitals are seeking alternatives to PVC plastic medical devices, building products, and office supplies.

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